Production of ultrapure water for pharmaceutical industry using an integrated system textile ion exchanger – membrane processes

H. Mabrouki, D.E. Akretche


Abstract: Water is a key element of all socioeconomic processes. Ultrapure water, with hardness less than 1 ppm, is currently widely employed in a variety of industries, including the semiconductor industry, the pharmaceutical industry, and electric power generation.To produce water with high-purity from well water, different purification methods such as thermal and membrane processes are performed. EDI is mainly used for ultrapure water production.Usually, this process is integrated with reverse osmosis (RO) to produce EDI feed water with a hardness of less than 1 ppm. In this study, ultrapure water was produced from a water well using a novel integrated UF- Ion Exchanger Textile (UF-IET)- electrodeionization (EDI) system.The UF IET-TEXTILE permeate with a conductivity of 248 μS/cm was fed into the EDI cell to generate the ultrapure water. It has been revealed that the product conductivity decreased as the EDI current density increased and the feed velocity increased.The results obtained revealed that the suggested hybrid separation process UF- IET/EDI system is an innovative solution for ultrapure water production with lower energy consumption and investment than the conventional RO/EDI system.

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Singh, R. Production of high-purity water by membrane processes. Desalination and Water Treatment 3 (2009)99-110.

Gadipelly, C.; Pérez-González, A.; Yadav, G. D.; Ortiz, I.; Ibáñez, R.; Rathod, V. K.; & Marathe, K. V. Pharmaceutical industry wastewater: review of the technologies for water treatment and reuse. Industrial & Engineering Chemistry Research, 53 (2014) 11571-11592.

Melnik, L.; and D. Krysenko. Ultrapure Water: Properties, Production, and Use. Journal of Water Chemistry and Technology 41 (2019) 143-150.

Hu, J.; Y. Chen, L.; Zhu, Z.; Qian and X. Chen. Production of high purity water using membrane-free electrodeionization with improved resin layer structure. Separation And Purification Technology 164 (2016) 89-96.

Mandal, M. K., Sharma, M., Pandey, S., & Dubey, K. K. Membrane technologies for the treatment of pharmaceutical industry wastewater. Water and Wastewater Treatment Technologies (2019) 103-116.

Koltuniewicz, A. B. and E. Drioli. Membranes in clean technologies. Membranes 31(2008) 3-1

Rathi, B. S. and P. S. Kumar. Electrodeionization theory, mechanism and environmental applications. A review. Environmental Chemistry Letters 18 (2020) 1209-1227.

Wood, J.; J. Gifford.; J. Arba and M. Shaw. Production of ultrapure water by continuous electrodeionization. Desalination 250 (2010) 973-976.

Rathi, B. S.; P. S. Kumar and R. Parthiban. A review on recent advances in electrodeionization for various environmental applications. Chemosphere 289 (2022) 133223.

Ulusoy Erol, H. B.; C. N. Hestekin and J. A. Hestekin. Effects of resin chemistries on the selective removal of industrially relevant metal ions using wafer-enhanced electrodeionization.Membranes 11 (2021) 45.

Hakim, A. and I. Wenten. Mechanism of Ion Transfer in Electrodeionization (EDI) System. Advanced Science Letters 23 (2017) 5640-5642.

Jina, Q.; W. Yaob and X. Chenc. Removal of Cr (VI) from wastewater by simplified electrodeionization. DESALINATION AND WATER TREATMENT 183 (2020) 301-306.

Lafi, R.; L. Gzara; R. H. Lajimi and A. Hafiane. Treatment of textile wastewater by a hybrid ultrafiltration/electrodialysis process. Chemical Engineering and Processing-Process Intensification 132 (2018) 105-113.

Shen, X.; T. Li, X. Jiang and X. Chen. Desalination of water with high conductivity using membrane-free electrodeionization." Separation and Purification Technology 128 (2014) 39-44.

Nataraj, S.; S. Sridhar; I. Shaikha; D. Reddy and T. Aminabhavi. Membrane-based microfiltration/electrodialysis hybrid process for the treatment of paper industry wastewater. Separation and Purification Technology 57 (2007) 185-192.

Arar, Ö.; Ü. Yüksel, N. Kabay and M. Yüksel. Demineralization of geothermal water reverse osmosis (RO) permeate by electrodeionization (EDI) with mixed bed configuration. Desalination 342 (2014) 23-28.

Xu, J.; C.-Y. Chang and C. Gao. Performance of a ceramic ultrafiltration membrane system in pretreatment to seawater desalination. Separation and Purification Technology 75 (2010) 165-173.

Yang, Z.; Y. Zhou; Z. Feng; X. Rui; T. Zhang and Z. Zhang. A review on reverse osmosis and nanofiltration membranes for water purification. Polymers 11 (2019) 1252.

Saleem, H. and S. J. Zaidi. Nanoparticles in reverse osmosis membranes for desalination: A state of the art review. Desalination 475 (2020) 114171.

Anis, S. F.; R. Hashaikeh and N. Hilal. Reverse osmosis pretreatment technologies and future trends: A comprehensive review. Desalination 452 (2019) 159-195.

Soldatov, V.; A. Shunkevich; I. Elinson; J. Johann and H. Iraushek. Chemically active textile materials as efficient means for water purification. Desalination 124 (1999) 181-192.

Soldatov, V.; V. Zelenkovskii and L. Orlovskaya. Sorption of bivalent ions by a fibrous chelating ion

exchanger and the structure of sorption complexes. Reactive and Functional Polymers 71 (2011) 49-61.

Polikarpov, A.; A. Shunkevich; V. Grachek and G. Medyak. FIBAN fibrous ion exchangers: Synthesis, modification, application. Russian Journal of General Chemistry 87 (2017) 1418-1427.

Soldatov, V.; A. Shunkevich; H. Wasąg; L. Pawłowski and M. Pawłowska. Prospects of fibrous ion exchangers in technology of water purification. Environmental Engineering Studies (2003) 153-165.

Sazonova, V. ; O. Perlova ; N. Perlova and A. Polikarpov. Sorption of uranium (VI) compounds on fibrous anion exchanger surface from aqueous solutions. Colloid Journal 79 (2017) 270-277.

Kosandrovich, E. and V. Soldatov. Fibrous ion exchangers. Ion Exchange Technology I (2012) 299-371.

Siali, M. and C. Gavach. Transport competition between proton and cupric ion through a cation-exchange membrane.: I. Equilibrium properties of the system: membrane-CuSO4+ H2SO4 solution. Journal of membrane science 71 (1992) 181-188.

Novoselova, L. Yu, and E. E. Sirotkina. Polyolefinic fibrous ion-exchange materials: Properties and applications. Chem. Sustainable Dev 14 (2006) 199-213.

Krol, J.; M. Wessling and H. Strathmann. Concentration polarization with monopolar ion exchange membranes: current–voltage curves and water dissociation. Journal of Membrane Science 162 (1999) 145-154.

Light, T. S.; B. Kingman and A. C. Bevilacqua. The conductivity of low concentrations of CO2 dissolved in ultrapure water from 0-100 C. 209th American Chemical Society National Meeting (1995).

Yu, Z.; S. Peldszus and P. M. Huck. Adsorption characteristics of selected pharmaceuticals and an endocrine disrupting compound—Naproxen, carbamazepine and nonylphenol—on activated carbon. Water research 42 (2008) 2873-2882.

Bennett, A. Water processes and production: High and ultra-high purity water. Filtration & Separation 46 (2009) 24-27.

Lorain, O.; B. Hersant; F. Persin; A. Grasmick; N. Brunard and J. M. Espenan. "Ultrafiltration membrane pre-treatment benefits for reverse osmosis process in seawater desalting. Quantification in terms of capital investment cost and operating cost reduction. Desalination 203 (2007) 277-285.

Alventosa-deLara, E.; S. Barredo-Damas; M. Alcaina-Miranda and M. Iborra-Clar. Ultrafiltration technology with a ceramic membrane for reactive dye removal: optimization of membrane performance. Journal of hazardous materials 209 (2012) 492-500.

Rai, P. ; G. Majumdar ; S. D. Gupta and S. De. Effect of various pretreatment methods on permeat flux and quality during ultrafiltration of mosambi juice. Journal of food engineering 78 (2007) 561-568.

Vladisavljević, G.; P. Vukosavljević and B. Bukvić. Permeate flux and fouling resistance in ultrafiltration of depectinized apple juice using ceramic membranes. Journal of food engineering 60 (2003) 241-247.

Nagarale, R.; G. Gohil and V. K. Shahi. Recent developments on ion-exchange membranes and electro-membrane processes. Advances in colloid and interface science 119 (2006) 97-130.

Hongjun, F. H. W. Application of Electrodeionization (EDI) in the Water Treatment of Power Plant [J]. Water Purification Technology 2 (2002).

Bouhidel, K.-E. and A. Lakehal. Influence of voltage and flow rate on electrodeionization (EDI) process efficiency. Desalination 193 (2006) 411-421.

Wardani, A. K.; A. N. Hakim and I. G. Wenten. Combined ultrafiltration-electrodeionization technique for production of high purity water. Water Science and Technology 75 (2017) 2891-2899.

LV, H.-d.; X.-x. ZHANG and X.-m. ZHANG. Application of EDI in Making Ultra Pure Water [J]. Power System Engineering 4 (2006).

Prato, T. and C. Gallagher. Using EDI to meet the needs of pure water production. GE Power Water Water Process Technol (2010) 1-5.

Meng, H.; C. Peng; S. Song and D. Deng . Electro-regeneration mechanism of ion-exchange resins in electrodeionization. Surface Review and Letters 11 (2004) 599-605.

Council of Europe, E. P. C. European pharmacopoeia, 6th ed. Strasbourg, Council Of Europe (2007).


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